Visible Light Photoredox-Catalyzed Multicomponent Reactions

Oxidative three-component reactions for the direct synthesis of alpha-amino amides and imides from tertiary amines have been developed. These reactions involve the functionalization of C(sp(3))-H bonds adjacent to nitrogen atoms via mild aerobic oxidation using visible light photoredox catalysis. The protocols are applicable to a wide range of amines and isocyanides, as well as water and carboxylic acids, providing straightforward access to a variety of highly functionalized alpha-amino amides and imides.