Journal
ORGANIC LETTERS
Volume 15, Issue 14, Pages 3738-3741Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol401616a
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Funding
- EPFL
- SNF [200021_129874]
- F. Hoffmann-La Roche, Ltd.
- Swiss National Science Foundation (SNF) [200021_129874] Funding Source: Swiss National Science Foundation (SNF)
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A Lewis acid catalyzed Friedel-Crafts reaction between donor-acceptor aminocyclopropanes and indoles and other electron-rich aromatic compounds is reported. Indole alkylation at the C3 position was generally obtained for a broad range of functional groups and substitution patterns. In the case of C3-substituted indoles, C2 alkylation was observed. The reaction gives a rapid access to gamma amino acid derivatives present in numerous bioactive molecules.
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