4.8 Article

Copper-Catalyzed Synthesis of Substituted Benzothiazoles via Condensation of 2-Aminobenzenethiols with Nitriles

Journal

ORGANIC LETTERS
Volume 15, Issue 7, Pages 1598-1601

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol400379z

Keywords

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Funding

  1. National Natural Science Foundation of China [20932002]
  2. National Basic Research Program of China (973 Program) [2011CB808600]
  3. Guangdong Natural Science Foundation [1035106410-1000000]
  4. China Postdoctoral Science Foundation [2011M501318]
  5. Fundamental Research Funds for the Central Universities [2012ZB0011]

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An efficient and convenient method was developed for the formation of 2-substituted benzothiazoles via a copper-catalyzed condensation of 2-aminobenzenethiols with nitriles. The developed method is applicable to a wide range of nitriles containing different functional groups furnishing excellent yields of the corresponding products.

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