Journal
ORGANIC LETTERS
Volume 16, Issue 1, Pages 174-177Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol4031606
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Compound 1, a potent and irreversible inhibitor of beta-lactamases, is in clinical trials with beta-lactam antibiotics for the treatment of serious and antibiotic-resistant bacterial infections. A short, scalable, and cost-effective route for the production of this densely functionalized polycyclic molecule is described.
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