Journal
ORGANIC LETTERS
Volume 15, Issue 19, Pages 5028-5031Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol402358k
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- Singapore National Research Foundation (NRF)
- Singapore Economic Development Board (EDB)
- GlaxoSmithKline (GSK)
- Nanyang Technological University (NTU)
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The direct gamma-carbon functionalization of alpha,beta-unsaturated esters via N-Heterocyclic Carbene (NHC) catalysis is disclosed. This catalytically generated nucleophilic gamma-carbon undergoes highly enantioselective additions to hydrazones. The resulting delta-lactam products can be readily transformed to optically enriched pipecolic acid derivatives.
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