4.8 Article

Pd-Catalyzed Oxidative CH/CH Direct Coupling of Heterocyclic N-Oxides

Journal

ORGANIC LETTERS
Volume 15, Issue 18, Pages 4682-4685

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol4019776

Keywords

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Funding

  1. Natural Science Foundation of China [21272174]
  2. Key Projects of Shanghai in Biomedicine [08431902700]
  3. Scientific Research Foundation of the State Education Ministry for Returned Overseas Chinese Scholars

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A highly efficient protocol for C-H/C-H cross-coupling has been found to occur between 2-aryl-1,2,3-triazole N-oxides and pyridine N-oxide derivatives. In addition, two homocoupling reactions of 2-substituted 1,2,3-triazole N-oxides and some pyridine N-oxide derivatives were developed. A possible pathway of C-H/C-H direct coupling is discussed.

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