4.8 Article

Direct Access to Enantioenriched Spiroacetals through Asymmetric Relay Catalytic Three-Component Reaction

Journal

ORGANIC LETTERS
Volume 15, Issue 3, Pages 460-463

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol303188u

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Funding

  1. NSFC [21232007]
  2. MOST [2010CB833300]
  3. BASF
  4. Ministry of Education

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The gold(I)/chiral Bronsted acid relay catalysis enabled a highly stereoselective three-component reaction of salicylaldehydes, anilines, and alkynols to give aromatic spiroacetals in high yields and stereoselectivities.

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