Journal
ORGANIC LETTERS
Volume 15, Issue 4, Pages 780-783Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol303435y
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- NIH [1R01GM085128, 1DP1GM106413, R01AI073829]
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Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC50 of 3 mu M, suggestive of a physiological role as an immunosuppressive agent.
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