4.8 Article

Silver-Catalyzed Radical Tandem Cyclization for the Synthesis of 3,4-Disubstituted Dihydroquinolin-2(1H)-ones

Journal

ORGANIC LETTERS
Volume 16, Issue 1, Pages 204-207

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol403196h

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Funding

  1. NSFC [21302042, 21172055]

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A silver-catalyzed tandem decarboxylative radical addition/cyclization of N-arylcinnamamides with aliphatic carboxylic acids is reported. This method affords a novel and straightforward route to various 3,4-disubstituted dihydroquinolin-2(1H)-ones in aqueous solution.

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