Journal
ORGANIC LETTERS
Volume 15, Issue 4, Pages 910-913Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol400065j
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Funding
- European Research Council
- Engineering and Physical Sciences Research Council [EP/I038578/1] Funding Source: researchfish
- EPSRC [EP/I038578/1] Funding Source: UKRI
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ortho-Arylation of ortho-substituted benzoic acids is a challenging process due to the tendency of the reaction products toward Pd-catalyzed protodecarboxylation. A simple method for preventing decarboxylation in sterically hindered benzoic acids is reported. The method described represents a reliable and broadly applicable entry to 2-aryl-6-substituted benzoic acids.
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