4.8 Article

Synthesis and Application of Palladium Precatalysts that Accommodate Extremely Bulky Di-tert-butylphosphino Biaryl Ligands

Journal

ORGANIC LETTERS
Volume 15, Issue 11, Pages 2876-2879

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol401208t

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Funding

  1. National Institutes of Health [GM46059, GM58160]
  2. Amgen
  3. National Science Foundation [CHE 9808061, DBI 9729592]

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A series of palladacyclic precatalysts that incorporate electron-rich di-fert-butylphosphino biaryl ligands is reported. These precatalysts are easily prepared, and their use provides a general means of employing bulky ligands in palladium-catalyzed cross-coupling reactions. The application of these palladium sources to various C-N and C-O bond-forming processes is also described.

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