Journal
ORGANIC LETTERS
Volume 15, Issue 13, Pages 3262-3265Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol401291n
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Grants-in-Aid for Scientific Research [25670043, 25860074] Funding Source: KAKEN
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Three new dimeric bromopyrrole alkaloids, nagelamides X-Z (1-3), were isolated from a marine sponge Agelas sp. Nagelamides X (1) and Y (2) possess a novel tricyclic skeleton consisting of spiro-bonded tetrahydrobenzaminoimidazole and aminoimidazolidine moieties. Nagelamide Z (3) is the first dimeric bromopyrrole alkaloid involving the C-8 position in dimerization. The structures of 1-3 were elucidated on the basis of spectroscopic data. Nagelamides X-Z (1-3) exhibited antimicrobial activity.
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