4.8 Article

Straightforward Synthesis of Dihydrobenzofurans and Benzofurans from Arynes

Journal

ORGANIC LETTERS
Volume 15, Issue 15, Pages 3938-3941

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol4017063

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Funding

  1. Ministry of Education, Culture, Sports, Science and Technology of Japan
  2. Grants-in-Aid for Scientific Research [24790032] Funding Source: KAKEN

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Synthesis of dihydrobenzofurans was achieved by a route involving the insertion of arynes into formamides followed by trapping with zinc enolates of alpha-chlorinated methines. Benzofurans were generated from dihydrobenzofurans having a ketone group via the addition of an ethyl anion, the retro-aldol type reaction, and the elimination of an amino group.

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