4.8 Article

Base-Catalyzed Diastereoselective [3+3] Annulation of 3-Isothiocyanatooxindoles and Azomethine Imines

Journal

ORGANIC LETTERS
Volume 15, Issue 19, Pages 4988-4991

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol402295m

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Funding

  1. NSFC [20932003, 91213302, 21272102, 21202071]
  2. National S&T Major Project of China [2012ZX09504001-003]

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An unprecedented diastereoselective [3 + 3] annulation of 3-isothiocyanatooxindoles and azomethine imines was catalyzed by Et3N, affording 3,3'-triazinyl spirooxindoles in excellent yields and diastereoselectivities under mild conditions.

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