4.8 Article

Enantioselective Chlorocyclization of Indole Derived Benzamides for the Synthesis of Spiro-indolines

Journal

ORGANIC LETTERS
Volume 15, Issue 16, Pages 4266-4269

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol4020943

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Funding

  1. National Basic Research Program of China (973 Program) [2010CB833300]
  2. National Natural Science Foundation of China [20923005, 21025209, 21121062]
  3. Chinese Academy of Sciences

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(DHQD)(2)PHAL catalyzed enantioselective chlorocyclization of indole derived benzamides was realized. Spiro-indolines containing a continuous quaternary carbon center and tertiary carbon center were obtained in good yields with excellent enantioselectivity (up to 90% yield and 96% ee).

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