4.8 Article

Asymmetric Diels-Alder Reaction of 3-Olefinic Benzofuran-2-ones and Polyenals: Construction of Chiral Spirocyclic Benzofuran-2-ones

Journal

ORGANIC LETTERS
Volume 16, Issue 1, Pages 114-117

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol403094a

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Funding

  1. Most [2010CB833300, 2012CB821600]
  2. NSFC [21390400, 21172112, 21172118]
  3. Program for New Century Excellent Talents in University [NCET-12-0279]
  4. State Key Laboratory on Elemento-organic Chemistry

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A highly enantioselective Diels-Alder reaction of 3-olefinic benzofuran-2-ones with polyenals catalyzed by diphenylprolinolsilyl ether through a trienamine activation strategy was developed.

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