4.8 Article

Ru(II)-Catalyzed ortho-C-H Amination of Arenes and Heteroarenes at Room Temperature

Journal

ORGANIC LETTERS
Volume 15, Issue 20, Pages 5286-5289

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol402515s

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Funding

  1. Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
  2. CAS/SAFEA International Partnership Program for Creative Research Teams
  3. Recruitment Program of Global Experts

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The Rupp-catalyzed ortho-C-H amination directed by a weakly coordinating amide auxiliary with O-benzoyl hydroxylamines at room temperature has been achieved. This reaction is compatible with heterocycles including pyrazole, thiophene, benzothiophene, furan, benzofuran, and indole.

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