4.8 Article

Indium Triiodide Catalyzed Reductive Functionalization of Amides via the Single-Stage Treatment of Hydrosilanes and Organosilicon Nucleophiles

Journal

ORGANIC LETTERS
Volume 15, Issue 13, Pages 3452-3455

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol4015317

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Funding

  1. Ministry of Education, Culture, Sports, Science and Technology (Japan)
  2. Grants-in-Aid for Scientific Research [24655030, 24106725, 24750090] Funding Source: KAKEN

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The indium triiodide catalyzed single-stage cascade reaction of N-sutfonyl amides with hydrosilanes and two types of organosilicon nucleophiles such as silyl cyanide and silyl enolates selectively promoted deoxygenative functionalization to give alpha-cyanoamines and beta-aminocarbonyl compounds, respectively.

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