4.8 Article

Arylations of Substituted Enamides by Aryl Iodides: Regio- and Stereoselective Synthesis of (Z)-β-Amido-β-Arylacrylates

Journal

ORGANIC LETTERS
Volume 15, Issue 17, Pages 4604-4607

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol402215f

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Funding

  1. National Natural Science Foundation of China [21272201]
  2. Yunnan University, Yunnan Province, China

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Arylations of substituted enamides by aryl iodides were achieved for the first time via an unusual PdCl2(COD)/Ag3PO4 catalytic system. A broad range of (2)-beta-amido-beta-arylacrylates were prepared regio- and stereoselectively in a highly efficient manner.

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