4.8 Article

Selective and Sensitive Superoxide Detection with a New Diselenide-Based Molecular Probe in Living Breast Cancer Cells

Journal

ORGANIC LETTERS
Volume 16, Issue 2, Pages 410-412

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol4033013

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Funding

  1. NRF (National Research Foundation) of Korea [2011-0017280]
  2. Institute of Basic Science (IBS), Korea
  3. National Research Foundation of Korea [2011-0017280] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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A diselenide-based BODIPY probe was prepared; it was found to be sensitive and selective for superoxide in giving [-Se(O)Se(O)-] oxidation. Probing was reversible through the use of biothiols; Se-77 NMR and other types of spectroscopy were employed. Practical medicinal utility was demonstrated in MCF-7/ADR cancer cells.

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