4.8 Article

Silver-Catalyzed Enantioselective Desymmetrization: Facile Access to Spirolactone-Pyrrolidines Containing a Spiro Quaternary Stereogenic Center

Journal

ORGANIC LETTERS
Volume 15, Issue 9, Pages 2250-2253

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol400821q

Keywords

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Funding

  1. 973 Program [2011CB808600]
  2. National Natural Science Foundation of China [20972117, 21172176]
  3. Fundamental Research Funds for the Central Universities
  4. Large-scale Instrument And Equipment Sharing Foundation of Wuhan University
  5. [NCET-10-0649]
  6. [IRT1030]

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An unprecedented Ag(I)-catalyzed asymmetric desymmetrization of Spiro cyclohexadienone lactones has been developed successfully, which performs well over a broad scope of substrates and provides a facile access to optically active spirolactone-pyrrolidines in high yields with excellent levels of diastereo-/enantioselectivities.

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