4.8 Article

A Palladium-Catalyzed Regioselective Hydroesterification of Alkenylphenols to Lactones with Phenyl Formate as CO Source

Journal

ORGANIC LETTERS
Volume 16, Issue 1, Pages 186-189

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol403171p

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Funding

  1. National Natural Science Foundation of China [21202082]
  2. Nanjing University

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An effective Pd(OAc)(2)-PPh3 catalyzed hydroesterification of alkenylphenols with phenyl formate as CO surrogate is described. A variety of lactones are obtained in generally high yields with high regioselectivities. In one case, 76% ee is obtained with a chiral ligand.

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