Journal
ORGANIC LETTERS
Volume 16, Issue 1, Pages 66-69Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol403040g
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Funding
- National Natural Science Foundation of China [21372148]
- Program for Chang Jiang Scholars and Innovative Research Team in University [IRT 1070]
- Distinguished Doctoral Research Funds of Shaanxi Normal University [X2010YB06]
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An unprecedented Rh-catalyzed direct methylation of ketones with N,N'-dimethylformamide (DMF) is disclosed. The reaction shows a broad substrate scope, tolerating both aryl and alkyl ketones with various substituents. Mechanistic studies suggest that DMF delivers a methylene fragment followed by a hydride in the methylation process.
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