4.8 Article

Reaction of Cyclic α-Oxoketene Dithioacetals with Methylene Isocyanides: A Novel Pyrrole Annulation - Ring-Expansion Domino Process

Journal

ORGANIC LETTERS
Volume 15, Issue 20, Pages 5250-5253

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol402469v

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Funding

  1. JNCASR, CSIR, New Delhi

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The title reaction provides a direct entry to a range of biologically relevant annulated pyrroles via a domino process involving a regioselective one-carbon homologation of cyclic ketones as the key step.

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