4.8 Article

A Fluorescent Ratiometric Chemodosimeter for Cu2+ Based on TBET and Its Application in Living Cells

Journal

ORGANIC LETTERS
Volume 15, Issue 3, Pages 492-495

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol3032889

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Funding

  1. NSF of China [21136002, 20923006, 21222605, 21272030, 21076032]
  2. National Basic Research Program of China [2009CB724706, 2013CB733702]
  3. National High Technology Research and Development Program of China (863 Program) [2011AA02A105]

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Based on a through bond energy transfer (TBET) between Rhodamlne and a naphthalimide fluorophore, a fluorescent ratiometric chemodosimeter AM was designed and prepared for single selective detection of Cu2+ in aqueous solution and in living cells, as Cu2+ acts as not only a selective recognizing guest but also a hydrolytic promoter.

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