Journal
ORGANIC LETTERS
Volume 15, Issue 4, Pages 960-963Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol400149j
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We report a set of concise and efficient routes for the chemical synthesis of human insulin using a two- or three-step combination procedure that employs Trt, Acm, and t-Bu cysteine protection schemes. Starting with resin-bound assembled A and B chains, human insulin can be obtained within the span of a single work day in 5.4% overall yield based on the crude A or B chain.
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