Journal
ORGANIC LETTERS
Volume 15, Issue 15, Pages 3848-3851Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol401470y
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21172069, 21190033]
- Innovation Program of Shanghai Municipal Education Commission [12ZZ050]
- Basic Research Program of the Shanghai Committee of Science and Technology [13NM1400802]
- Fundamental Research Funds for the Central Universities
Ask authors/readers for more resources
Intermolecular benzylic methylene functionalization of exo-cyclic enol ethers has been achieved using imines as reagents and potassium tertbutoxide as the catalyst. Depending on the solvent used, the reaction proceeds by two pathways. In THF, an addition/elimination reaction of exo-cyclic enol ethers with imines provides dihydroisobenzofuran derivatives in good yield. In DMSO, an addition/ring-opening/cyclization cascade reaction occurs with unexpected cleavage of C-O and C-C bonds, affording isoquinolin-1(2H)-one products in high yield under ambient reaction conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available