Journal
ORGANIC LETTERS
Volume 15, Issue 11, Pages 2594-2597Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol400618k
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Funding
- NSFC [21272075]
- NCET [12-0178]
- Shanghai Pujiang Program [12PJ1402500]
- Shanghai Talent Development Support [2011022]
- CPSF [2012M520858]
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A novel Pd-catalyzed double C-S bond formation coupling reaction has been developed. This protocol, in which Na2S2O3 was used as sulfurating reagent in metal-catalyzed reactions, provides an efficient method for the synthesis of substituted 1,4-benzothiazine derivates, which are structural elements of numerous bioactivity molecules rendering this protocol attractive to both synthetic and medicinal chemistry.
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