Journal
ORGANIC LETTERS
Volume 15, Issue 18, Pages 4702-4705Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol4025293
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Funding
- CRI from NRF [2009-0081566]
- CAP [PBC066]
- Korea Research Council of Fundamental Science and Technology (KRCF)
- Korea Basic Science Institute [D33400]
- National Research Council of Science & Technology (NST), Republic of Korea [D33400] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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A water-soluble T-1 magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal contrast agent 1 responds to the Cu2+ ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free copper ions in RAW 264.7 cells even at the micromolar level.
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