Journal
ORGANIC LETTERS
Volume 15, Issue 11, Pages 2636-2639Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol400884v
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Funding
- IISER Pune
- Department of Biotechnology (DBT) [BT/05/IYBA/2011]
- Wellcome Trust-DBT (WT-DBT) India Alliance
- Council for Scientific and Industrial Research (CSIR)
- WT-DBT India Alliance
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The design, synthesis, and development of INDQ/NO, a novel nitric oxide (NO) prodrug targeted by a bioreductive trigger, are described. INDQ/NO, an indolequinone-diazeniumdiolate is found to be metabolized to produce NO by DT-diaphorase, a bioreductive enzyme that is overexpressed in certain cancers and hypoxic tumors. Cell-based assays revealed that INDQ/NO induces DNA damage and is a potent inhibitor of cancer cell proliferation.
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