Journal
ORGANIC LETTERS
Volume 15, Issue 13, Pages 3468-3471Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol401558z
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- Landesgraduiertenforderung Baden Wurttemberg
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In the presence of silver(I) fluoride, highly fluorinated olefins react readily under solvent-free conditions with arenes via CH-substitution. This transformation could be used to synthesize various methoxycarbonyltetrafluoroethylated aromatic triazenes and anisoles under high functional group tolerance. The method could be applied to the synthesis of a formal fluorinated bioisostere of the NSAID flurbiprofen. To the best of our knowledge, this is the first example which uses highly fluorinated olefins for the perfluoroalkylation of aromatic substrates.
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