Pd-Catalyzed Alkynylation of 2-Chloroacetates and 2-Chloroacetamidds with Potassium Alkynyltrifluoroborates

The synthesis of beta,gamma-alkynyl esters and amides using air-stable potassium alkynyltrifluoroborates as nucleophilic partners in a mild Suzuki-Miyaura cross-coupling reaction has been achieved. Propargyl esters and amides were obtained In high yields using a low catalyst loading, and the substrate scope of the reaction has been significantly improved over previous methods.