Journal
ORGANIC LETTERS
Volume 15, Issue 3, Pages 610-612Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol3034274
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- Ministry of Education, Culture, Sports, Science, and Technology of Japan
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A manzamine related alkaloid, zamamiphidin A (1), consisting of a new heptacyclic ring system has been isolated from an Okinawan marine sponge Amphimedon sp. The structure of 1 including the relative stereochemistry was elucidated on the basis of the spectroscopic data. Compound 1 showed antibacterial activity against Staphylococcus aureus (MIC, 32 mu g/mL).
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