4.8 Article

Macrocyclic Glycohybrid Toolbox Identifies Novel Antiangiogenesis Agents from Zebrafish Assay

Journal

ORGANIC LETTERS
Volume 15, Issue 3, Pages 432-435

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol3032297

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Funding

  1. DST [SR/S1/OC-30/2010]
  2. DBT [102/IFD/SAN/PR 2862/2010-11]
  3. CSIR

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A practical and modular approach to obtain a diverse set of 14-membered macrocyclic compounds from carbohydrates is developed that utilizes functional groups at C-1 and C-5. The evaluation of this toolbox in various zebrafish assays led to the identification of 2.7f as an antianglogenesis agent.

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