Journal
ORGANIC LETTERS
Volume 15, Issue 14, Pages 3674-3677Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol401549y
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Funding
- 973 Program [2010CB833200, 2009CB118901]
- National Natural Science Foundation of China [21072214]
- Open Funding Project of the State Key Laboratory of Bioreactor Engineering
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Analysis of naphthyridinomycin gene cluster revealed that this antibiotic is generated by nonribosomal peptide synthetase (NRPS) machinery. However, four modules encoded by two genes do not correspond with the structural units in the final product. Genetic and biochemical characterization of the gene cluster suggested that the leader peptide mechanism for the NRPS assembly line was Involved in biosynthesis of this tetrahydroisoquinoline alkaloid.
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