4.8 Article

Palladium Catalyzed Cyclizations of Oxime Esters with 1,2-Disubstituted Alkenes: Synthesis of Dihydropyrroles

Journal

ORGANIC LETTERS
Volume 15, Issue 17, Pages 4616-4619

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol4023112

Keywords

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Funding

  1. EPSRC [EP/J007455/1, EP/G036764/1]
  2. Bristol Chemical Synthesis CDT
  3. Royal Society for a University Research Fellowship
  4. EPSRC [EP/K03927X/1, EP/J007455/1] Funding Source: UKRI
  5. Engineering and Physical Sciences Research Council [981192, EP/J007455/1, EP/K03927X/1] Funding Source: researchfish

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Pd-catalyzed cyclizations of oxime esters with 1,2-dialkylated alkenes provide an entry to chiral dihydropyrroles. Substrate and catalyst controlled strategies for selective product formation (vs alternative pyrroles) are outlined.

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