4.8 Article

A New Pyrrole Synthesis via Silver(I)-Catalyzed Cycloaddition of Vinylogous Diazoester and Nitrile

Journal

ORGANIC LETTERS
Volume 15, Issue 7, Pages 1421-1423

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol400062w

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Funding

  1. Hoffmann-La Roche

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A new synthesis of di- and trisubstituted pyrroles was achieved by treating in situ generated vinylogous diazoesters and readily available nitriles with a catalytic amount of silver(I) antimony hexafluoride at room temperature. This method showcased the potential of utilizing silver(I) carbenoids in preparing heterocyclic compounds.

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