Concise Synthesis of Reduced Propionates by Stereoselective Reductions Combined with the Kobayashi Reaction

A concise and straightforward synthesis of 2,4,6-trimethyloctanoates was established by using the sequence of the vinylogous Mukalyama aldol reaction and regio- and stereoselective reduction reactions. All Isomers were obtained selectively in a few steps. The short step synthesis of septoriamycin A, an antimalarial and antileishmanial agent, has been achieved by this methodology.