Journal
ORGANIC LETTERS
Volume 15, Issue 15, Pages 4022-4025Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol401838p
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Funding
- National Science Foundation of China [21136002, 21076032, 20923006]
- National Basic Research Program of China [2009CB724706, 2012CB733702]
- National High Technology Research and Development Program of China (863 program) [2011AA02A105]
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Based on modulation of the conjugated polymethine pi-electron system of a cyanine dye derivative, a ratiometric near-infared fluorescent probe (Cy7A) for hydrazine (N2H4) has been designed and synthesized. Cy7A can be selectively hydrazinolysized with great changes in its fluorescent excitation/emission profiles, which makes it possible to detect N2H4 in water samples and living cells and, for the first time, visualize N2H4 in living mice.
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