4.8 Article

Molecular Iodine Catalyzed Cross-Dehydrogenative Coupling Reaction between Two sp3 C-H Bonds Using Hydrogen Peroxide

Journal

ORGANIC LETTERS
Volume 15, Issue 3, Pages 574-577

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol303389t

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Funding

  1. Japan Society for the Promotion of Science (JSPS) [24790015]
  2. Grants-in-Aid for Scientific Research [24790015] Funding Source: KAKEN

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A useful method for molecular iodine catalyzed oxidative C-C bond formation between tertiary amines and a carbon nucleophile using hydrogen peroxide as the terminal oxidant is reported. This is the first report of a molecular Iodine catalyzed cross-dehydrogenative coupling (CDC) reaction between two sp(3) C-H bonds.

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