4.8 Article

Tandem Michael Addition/Cyclization Reaction of 2,3-Allenoates with Organozincs: Facile Synthesis of Isocoumarins

Journal

ORGANIC LETTERS
Volume 15, Issue 15, Pages 3884-3887

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol401625t

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Funding

  1. National Natural Science Foundation of China [21232006]
  2. National Basic Research Program of China [2011CB808700]

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A series of isocoumarin derivatives have been synthesized via the reaction of 2-(o-aimethoxycarbonyl)phenyI)-2,3-allenoates with organozincs in CH2Cl2 at room temperature (for diallrylzinc) or 100 degrees C (for Ph2Zn) through a tandem Michael additionfintramolecular cyclization process.

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