Journal
ORGANIC LETTERS
Volume 15, Issue 14, Pages 3514-3517Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol401071j
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Funding
- Ministry of Education, Culture, Sports, and Technology of Japan
- Grants-in-Aid for Scientific Research [24580166] Funding Source: KAKEN
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Biosynthetic origin of 2H-tetrahydro-4,6-dioxo-1,2-oxazine, an unprecedented structural unit first discovered in alchivemycin A (1), was investigated by feeding C-13-labeled precursors. Incorporations of both [1-C-13]glycine and [1-C-13]-N-hydroxyglycine into the carbon at the 4-position of this six-membered ring indicate that the hydrooxazine ring is assembled through a PKS-NRPS hybrid pathway. Additionally, alchivemycin B (2), a deoxygenated analog of 1, was isolated and its relative and absolute configurations were determined by spectroscopic analysis including NMR and CD and X-ray crystallography.
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