Modernized Low Pressure Carbonylation Methods in Batch and Flow Employing Common Acids as a CO Source

Carbonylation reactions, such as Heck, Sonogashira, and radical carbonylations, were successfully carried out in a two-chamber reactor where carbon monoxide was produced ex situ by the Morgan reaction (dehydration of formic acid by sulfuric acid). By a subsequent application In a microflow system using a tube-in-tube reactor where gas-permeable Teflon AF2400 was used as the inner tube, it is demonstrated that formic acid/sulfuric acid can be employed concomitantly with an amine base such as triethylamine in the Heck aminocarbonylation of aryl iodide.