4.8 Article

Synthesis of Functionalized Spiroindolines via Palladium-Catalyzed Methine C-H Arylation

Journal

ORGANIC LETTERS
Volume 15, Issue 6, Pages 1354-1357

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol400380y

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Funding

  1. European Research Council under the European Community [257891]
  2. EPFL

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The synthesis of cyclopropyl spiroindolines is described using an intramolecular palladium(0)-catalyzed C-H functionalization of a methine C(sp(3))-H bond. This transformation can be coupled with intermolecular Suzuki couplings or direct arylations of heteroaromatics to access functionalized indoline scaffolds in a single step.

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