Journal
ORGANIC LETTERS
Volume 15, Issue 22, Pages 5778-5781Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol402800a
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Funding
- Plan Nacional de I+D [CTQ2009-07109]
- MICINN/MINECO, Spain
- European Regional Development (FEDER) Funds
- Spanish Research Council
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The development of peptide libraries by site-selective modification of a few parent peptides would save valuable time and materials in discovery processes, but still is a difficult synthetic challenge. Herein natural hydroxyproline is introduced as a convertible unit for the production of a variety of optically pure amino acids, including expensive N-alkyl amino acids, and to achieve the mild, efficient, and site-selective modification of peptides.
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