Journal
ORGANIC LETTERS
Volume 15, Issue 23, Pages 6094-6097Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol402988s
Keywords
-
Categories
Funding
- AstraZeneca
- EPSRC
- EPSRC [EP/J00894X/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/J00894X/1] Funding Source: researchfish
Ask authors/readers for more resources
Ring-opening of cyclic sulfamidates with propargylic sulfonamides yielded substrates for a gold-catalyzed cyclization to yield tetrahydropyrazines. Manipulation of the tetrahydropyrazines, by reduction or using multicomponent reactions, yielded piperazine scaffolds in which substitution of the carbon atoms was varied. Such scaffolds may have value in the synthesis of novel screening compounds with lead-like molecular properties.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available