Journal
ORGANIC LETTERS
Volume 15, Issue 1, Pages 180-183Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol303240a
Keywords
-
Categories
Funding
- Marie Curie ITN BIOTRAINS' [238531]
- MICINN
Ask authors/readers for more resources
A series of synthetic nicotinamide cofactors were synthesized to replace natural nicotinamide cofactors and promote enoate reductase (ER) catalyzed reactions without compromising the activity or stereoselectivity of the bioreduction process. Conversions and enantioselectivities of >99% were obtained for C=C bioreductions, and the process was successfully upscaled. Furthermore, high chemoselectivity was observed when employing these nicotinamide cofactor mimics (mNADs) with crude extracts in ER-catalyzed reactions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available