4.8 Article

Biomass Conversion to High Value Chemicals: From Furfural to Chiral Hydrofuroins in Two Steps

Journal

ORGANIC LETTERS
Volume 14, Issue 15, Pages 4014-4017

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol3018402

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Funding

  1. ICIQ Foundation
  2. Consolider Ingenio [CSD2006-0003]

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Catalytic asymmetric transfer hydrogenation of rac-furoin and furil produces hydrofuroin with up to 99% ee and 9:1 dr. This reaction provides an exceptionally easy access to optically active hydrofuroins in two straightforward steps from biomass-derived furfural (global production 200 000-300 000 t annually) using benzoin condensation.

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