Journal
ORGANIC LETTERS
Volume 14, Issue 13, Pages 3364-3367Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol301343n
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Funding
- MOST [2010CB833805, 2012AA092104]
- CAS [KZCX2-YW-JC202, KSCX2-EW-G-12, KZCX2-YW-G-065]
- NSFC [31125001, 41006089, 41106143, 40906075]
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A PCR-based screening approach led to the identification of a deep-sea-derived Streptomyces sp. SCSIO 03032 capable of producing new bisindole alkaloids spiroindimicins A-D (1-4). Structural elucidation of these compounds revealed the presence of unusual [5,6] or [5,5] spiroring containing skeletons. Spiroindimicins B-D (2-4) with a [5,5] spiro-ring exhibited moderate cytotoxicities against several cancer cell lines.
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