4.8 Article

Ruthenium-Catalyzed Pyrrole Synthesis via Oxidative Annulation of Enamides and Alkynes

Journal

ORGANIC LETTERS
Volume 15, Issue 1, Pages 136-139

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol303159h

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Funding

  1. NSFC [21072097, 21072101]
  2. SRFDP [20110031110009]

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An efficient and regioselective ruthenium-catalyzed oxidative annulation of enamides with alkynes via the cleavage of C(sp(2))-H/N-H bonds is reported. The reactions can afford N-acetyl substituted or N-unsubstituted pyrroles by altering the reaction conditions slightly.

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